Targeting Metabolism as a Platform for Inducing Allograft Tolerance in the Absence of Long-Term Immunosuppression
Transplant tolerance in the absence of long-term immunosuppression has been an elusive goal for solid organ transplantation. Recently, it has become clear that metabolic reprogramming plays a critical role in promoting T cell activation, differentiation, and function. Targeting metabolism can prefer...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-04-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2020.00572/full |
| _version_ | 1818528174692106240 |
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| author | Chih-Hsien Cheng Chih-Hsien Cheng Chih-Hsien Cheng Chen-Fang Lee Chen-Fang Lee Chen-Fang Lee Byoung Chol Oh Georg J. Furtmüller Chirag H. Patel Chirag H. Patel Gerald Brandacher Jonathan D. Powell Jonathan D. Powell |
| author_facet | Chih-Hsien Cheng Chih-Hsien Cheng Chih-Hsien Cheng Chen-Fang Lee Chen-Fang Lee Chen-Fang Lee Byoung Chol Oh Georg J. Furtmüller Chirag H. Patel Chirag H. Patel Gerald Brandacher Jonathan D. Powell Jonathan D. Powell |
| author_sort | Chih-Hsien Cheng |
| collection | DOAJ |
| description | Transplant tolerance in the absence of long-term immunosuppression has been an elusive goal for solid organ transplantation. Recently, it has become clear that metabolic reprogramming plays a critical role in promoting T cell activation, differentiation, and function. Targeting metabolism can preferentially inhibit T cell effector generation while simultaneously promoting the generation of T regulatory cells. We hypothesized that costimulatory blockade with CTLA4Ig in combination with targeting T cell metabolism might provide a novel platform to promote the induction of transplant tolerance. |
| first_indexed | 2024-12-11T06:46:15Z |
| format | Article |
| id | doaj.art-7b72a5d570b14a228e3d3de71e15fdd9 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-11T06:46:15Z |
| publishDate | 2020-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-7b72a5d570b14a228e3d3de71e15fdd92022-12-22T01:17:04ZengFrontiers Media S.A.Frontiers in Immunology1664-32242020-04-011110.3389/fimmu.2020.00572512649Targeting Metabolism as a Platform for Inducing Allograft Tolerance in the Absence of Long-Term ImmunosuppressionChih-Hsien Cheng0Chih-Hsien Cheng1Chih-Hsien Cheng2Chen-Fang Lee3Chen-Fang Lee4Chen-Fang Lee5Byoung Chol Oh6Georg J. Furtmüller7Chirag H. Patel8Chirag H. Patel9Gerald Brandacher10Jonathan D. Powell11Jonathan D. Powell12Sidney∼Kimmel Comprehensive Cancer Research Center, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, United StatesBloomberg∼Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, MD, United StatesDepartment of Liver and Transplantation Surgery, Chang-Gung Memorial Hospital, Chang-Gung Transplantation Institute, Chang-Gung University College of Medicine, Taoyuan, TaiwanSidney∼Kimmel Comprehensive Cancer Research Center, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, United StatesBloomberg∼Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, MD, United StatesDepartment of Liver and Transplantation Surgery, Chang-Gung Memorial Hospital, Chang-Gung Transplantation Institute, Chang-Gung University College of Medicine, Taoyuan, TaiwanVascularized Composite Allotransplantation Laboratory, Department of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, United StatesVascularized Composite Allotransplantation Laboratory, Department of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, United StatesSidney∼Kimmel Comprehensive Cancer Research Center, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, United StatesBloomberg∼Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, MD, United StatesVascularized Composite Allotransplantation Laboratory, Department of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, United StatesSidney∼Kimmel Comprehensive Cancer Research Center, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, United StatesBloomberg∼Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, MD, United StatesTransplant tolerance in the absence of long-term immunosuppression has been an elusive goal for solid organ transplantation. Recently, it has become clear that metabolic reprogramming plays a critical role in promoting T cell activation, differentiation, and function. Targeting metabolism can preferentially inhibit T cell effector generation while simultaneously promoting the generation of T regulatory cells. We hypothesized that costimulatory blockade with CTLA4Ig in combination with targeting T cell metabolism might provide a novel platform to promote the induction of transplant tolerance.https://www.frontiersin.org/article/10.3389/fimmu.2020.00572/fullmousemodeltransplantationimmunologymetabolismcostimulation blockade |
| spellingShingle | Chih-Hsien Cheng Chih-Hsien Cheng Chih-Hsien Cheng Chen-Fang Lee Chen-Fang Lee Chen-Fang Lee Byoung Chol Oh Georg J. Furtmüller Chirag H. Patel Chirag H. Patel Gerald Brandacher Jonathan D. Powell Jonathan D. Powell Targeting Metabolism as a Platform for Inducing Allograft Tolerance in the Absence of Long-Term Immunosuppression Frontiers in Immunology mouse model transplantation immunology metabolism costimulation blockade |
| title | Targeting Metabolism as a Platform for Inducing Allograft Tolerance in the Absence of Long-Term Immunosuppression |
| title_full | Targeting Metabolism as a Platform for Inducing Allograft Tolerance in the Absence of Long-Term Immunosuppression |
| title_fullStr | Targeting Metabolism as a Platform for Inducing Allograft Tolerance in the Absence of Long-Term Immunosuppression |
| title_full_unstemmed | Targeting Metabolism as a Platform for Inducing Allograft Tolerance in the Absence of Long-Term Immunosuppression |
| title_short | Targeting Metabolism as a Platform for Inducing Allograft Tolerance in the Absence of Long-Term Immunosuppression |
| title_sort | targeting metabolism as a platform for inducing allograft tolerance in the absence of long term immunosuppression |
| topic | mouse model transplantation immunology metabolism costimulation blockade |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2020.00572/full |
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