The role of hypermutation and collateral sensitivity in antimicrobial resistance diversity of Pseudomonas aeruginosa populations in cystic fibrosis lung infection

The role of hypermutation and collateral sensitivity in antimicrobial resistance diversity of Pseudomonas aeruginosa populations in cystic fibrosis lung infection

ABSTRACTPseudomonas aeruginosa is an opportunistic pathogen which causes chronic, drug-resistant lung infections in cystic fibrosis (CF) patients. In this study, we explore the role of genomic diversification and evolutionary trade-offs in antimicrobial resistance (AMR) diversity within P. aeruginos...

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Bibliographic Details
Main Authors: Jelly Vanderwoude, Sheyda Azimi, Timothy D. Read, Stephen P. Diggle
Format: Article
Language:English
Published: American Society for Microbiology 2024-02-01
Series:mBio
Subjects:
cystic fibrosis
population heterogeneity
antibiotic resistance
hypermutation
evolution
Online Access:https://journals.asm.org/doi/10.1128/mbio.03109-23

Internet

https://journals.asm.org/doi/10.1128/mbio.03109-23

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