Induction of Apoptosis by Isoalantolactone in Human Hepatocellular Carcinoma Hep3B Cells through Activation of the ROS-Dependent JNK Signaling Pathway

Induction of Apoptosis by Isoalantolactone in Human Hepatocellular Carcinoma Hep3B Cells through Activation of the ROS-Dependent JNK Signaling Pathway

Isoalantolactone (IALT) is one of the isomeric sesquiterpene lactones isolated from the roots of <i>Inula helenium</i> L. IALT is known to possess various biological and pharmacological activities, but its anti-cancer mechanisms are not well understood. The aim of the present study was t...

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Bibliographic Details
Main Authors: Min Yeong Kim, Hyesook Lee, Seon Yeong Ji, So Young Kim, Hyun Hwangbo, Shin-Hyung Park, Gi-Young Kim, Cheol Park, Sun-Hee Leem, Su Hyun Hong, Yung Hyun Choi
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Pharmaceutics
Subjects:
Isoalantolactone
HCC Hep3B cells
apoptosis
ROS
JNK
Online Access:https://www.mdpi.com/1999-4923/13/10/1627

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https://www.mdpi.com/1999-4923/13/10/1627

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