Repurposing tRNAs for nonsense suppression
Here, the authors report de novo design, optimization and characterization of tRNAs that decode UGA stop codons in E. coli. The structure of the ribosome in a complex with the designed tRNA bound to a UGA stop codon suggests that distinct A-site ligands (tRNAs versus release factors) induce distinct...
| Auteurs principaux: | , , , , , , , , , , |
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| Format: | Article |
| Langue: | English |
| Publié: |
Nature Portfolio
2021-06-01
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| Collection: | Nature Communications |
| Accès en ligne: | https://doi.org/10.1038/s41467-021-24076-x |