Type I interferon receptor (IFNAR2) deficiency reveals Zika virus cytopathicity in human macrophages and microglia

Type I interferon receptor (IFNAR2) deficiency reveals Zika virus cytopathicity in human macrophages and microglia

Macrophages are key target cells of Zika virus (ZIKV) infection, implicated as a viral reservoir seeding sanctuary sites such as the central nervous system and testes. This rests on the apparent ability of macrophages to sustain ZIKV replication without experiencing cytopathic effects. ZIKV infectio...

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Bibliographic Details
Main Authors: Aidan T. Hanrath, Catherine F. Hatton, Florian Gothe, Cathy Browne, Jane Vowles, Peter Leary, Simon J. Cockell, Sally A. Cowley, William S. James, Sophie Hambleton, Christopher J. A. Duncan
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Immunology
Subjects:
Zika virus
IFNAR2 deficiency
inborn errors of immunity
macrophages
type I interferons
cell death
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1035532/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.1035532/full

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