FBXW7 inactivation induces cellular senescence via accumulation of p53

FBXW7 inactivation induces cellular senescence via accumulation of p53

Abstract F-box and WD repeat domain containing 7 (FBXW7) acts as a substrate receptor of SKP1-CUL1-F-box (SCF) E3 ubiquitin ligase and plays crucial roles in the regulation of several cellular processes, including cell growth, division, and differentiation, by targeting diverse key regulators for de...

Full description

Bibliographic Details
Main Authors: Longyuan Gong, Danrui Cui, Dian Liu, Xiao Shen, Hui Pan, Xiufang Xiong, Yongchao Zhao
Format: Article
Language:English
Published: Nature Publishing Group 2022-09-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-022-05229-2

Internet

https://doi.org/10.1038/s41419-022-05229-2

Similar Items