N-Hexyl-0-glucosyl sphingosine, an inhibitor of glucosyl ceramide, β-glucosidase
A synthetic analog of glucocerebroside, N-hexyl-0-glucosyl sphingosine, was found to inhibit the glucosidase in rat spleen that hydrolyzes glucocerebroside. At a concentration of 1 μm, the analog inhibited the enzyme by 48%. The mode of action appeared to be competitive, probably aided by tight bind...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
1973-03-01
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| Series: | Journal of Lipid Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0022227520368991 |