Rationally introducing non-canonical amino acids to enhance catalytic activity of LmrR for Henry reaction

Rationally introducing non-canonical amino acids to enhance catalytic activity of LmrR for Henry reaction

Abstract The use of enzymes to catalyze Henry reaction has advantages of mild reaction conditions and low contamination, but low enzyme activity of promiscuous catalysis limits its application. Here, rational design was first performed to identify the key amino acid residues in Henry reaction cataly...

Full description

Bibliographic Details
Main Authors: Lan Wang, Mengting Zhang, Haidong Teng, Zhe Wang, Shulin Wang, Pengcheng Li, Jianping Wu, Lirong Yang, Gang Xu
Format: Article
Language:English
Published: SpringerOpen 2024-02-01
Series:Bioresources and Bioprocessing
Subjects:
Henry reaction
Catalytic activity
Rational design
Non-canonical amino acid
Molecular dynamics simulations
Online Access:https://doi.org/10.1186/s40643-024-00744-w

Internet

https://doi.org/10.1186/s40643-024-00744-w

Similar Items