Loss of Cardiac PFKFB2 Drives Metabolic, Functional, and Electrophysiological Remodeling in the Heart

Loss of Cardiac PFKFB2 Drives Metabolic, Functional, and Electrophysiological Remodeling in the Heart

Background Phosphofructo‐2‐kinase/fructose‐2,6‐bisphosphatase (PFK‐2) is a critical glycolytic regulator responsible for upregulation of glycolysis in response to insulin and adrenergic signaling. PFKFB2, the cardiac isoform of PFK‐2, is degraded in the heart in the absence of insulin signaling, con...

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Bibliographic Details
Main Authors: Kylene M. Harold, Satoshi Matsuzaki, Atul Pranay, Brooke L. Loveland, Albert Batushansky, Maria F. Mendez Garcia, Craig Eyster, Stavros Stavrakis, Ying Ann Chiao, Michael Kinter, Kenneth M. Humphries
Format: Article
Language:English
Published: Wiley 2024-04-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
echocardiography
electrocardiography
glucose
glycolysis
metabolism
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.123.033676

Internet

https://www.ahajournals.org/doi/10.1161/JAHA.123.033676

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