MGMT genomic rearrangements contribute to chemotherapy resistance in gliomas

MGMT genomic rearrangements contribute to chemotherapy resistance in gliomas

Chemotherapy resistance in recurrent gliomas is a large hurdle for successful therapy. Here, the authors show that some recurrent gliomas harbour O-6-methylguanine-DNA methyltransferase (MGMT) genomic rearrangements, and in vitro and in vivo these contribute to temozolomide resistance.

Bibliographic Details
Main Authors: Barbara Oldrini, Nuria Vaquero-Siguero, Quanhua Mu, Paula Kroon, Ying Zhang, Marcos Galán-Ganga, Zhaoshi Bao, Zheng Wang, Hanjie Liu, Jason K. Sa, Junfei Zhao, Hoon Kim, Sandra Rodriguez-Perales, Do-Hyun Nam, Roel G. W. Verhaak, Raul Rabadan, Tao Jiang, Jiguang Wang, Massimo Squatrito
Format: Article
Language:English
Published: Nature Portfolio 2020-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-17717-0

Internet

https://doi.org/10.1038/s41467-020-17717-0

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