Improved Sensitivity in Hydrophilic Interaction Liquid Chromatography-Electrospray-Mass Spectrometry after Removal of Sodium and Potassium Ions from Biological Samples

Improved Sensitivity in Hydrophilic Interaction Liquid Chromatography-Electrospray-Mass Spectrometry after Removal of Sodium and Potassium Ions from Biological Samples

Inorganic ions, such as sodium and potassium, are present in all biological matrices and are sometimes also added during sample preparation. However, these inorganic ions are known to hamper electrospray ionization -mass spectrometry (ESI-MS) applications, especially in hydrophilic interaction liqui...

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Bibliographic Details
Main Authors: Ida Erngren, Marika Nestor, Curt Pettersson, Mikael Hedeland
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Metabolites
Subjects:
hydrophilic interaction liquid chromatography
mass spectrometry
metabolomics
sample preparation
ion suppression
matrix effects
Online Access:https://www.mdpi.com/2218-1989/11/3/170

Internet

https://www.mdpi.com/2218-1989/11/3/170

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