Raloxifene Stimulates Estrogen Signaling to Protect Against Age- and Sex-Related Intervertebral Disc Degeneration in Mice

Raloxifene Stimulates Estrogen Signaling to Protect Against Age- and Sex-Related Intervertebral Disc Degeneration in Mice

Estrogen agonist raloxifene is an FDA-approved treatment of osteoporosis in postmenopausal women, which may also be a promising prophylactic for painful intervertebral disc (IVD) degeneration. Here, we hypothesized that 1) aging and biological sex contribute to IVD degeneration by reducing estrogen...

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Bibliographic Details
Main Authors: Neharika Bhadouria, Alycia G. Berman, Joseph M. Wallace, Nilsson Holguin
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
hormone replacement/receptor modulators
menopause
aging
therapeutics
ovariectomy (OVX)
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2022.924918/full

Internet

https://www.frontiersin.org/articles/10.3389/fbioe.2022.924918/full

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