Raloxifene Stimulates Estrogen Signaling to Protect Against Age- and Sex-Related Intervertebral Disc Degeneration in Mice
Estrogen agonist raloxifene is an FDA-approved treatment of osteoporosis in postmenopausal women, which may also be a promising prophylactic for painful intervertebral disc (IVD) degeneration. Here, we hypothesized that 1) aging and biological sex contribute to IVD degeneration by reducing estrogen...
| Հիմնական հեղինակներ: | , , , |
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| Ձևաչափ: | Հոդված |
| Լեզու: | English |
| Հրապարակվել է: |
Frontiers Media S.A.
2022-08-01
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| Շարք: | Frontiers in Bioengineering and Biotechnology |
| Խորագրեր: | |
| Առցանց հասանելիություն: | https://www.frontiersin.org/articles/10.3389/fbioe.2022.924918/full |