A non-invasive multipoint product temperature measurement for pharmaceutical lyophilization

Abstract Monitoring product temperature during lyophilization is critical, especially during the process development stage, as the final product may be jeopardized if its process temperature exceeds a threshold value. Also, in-situ temperature monitoring of the product gives the capability of creati...

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Bibliographic Details
Main Authors: Xiaofan Jiang, Petr Kazarin, Michael D. Sinanis, Ahmad Darwish, Nithin Raghunathan, Alina Alexeenko, Dimitrios Peroulis
Format: Article
Language:English
Published: Nature Portfolio 2022-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-16073-x