Gastric inhibitory polypeptide receptor antagonism suppresses intramuscular adipose tissue accumulation and ameliorates sarcopenia

Gastric inhibitory polypeptide receptor antagonism suppresses intramuscular adipose tissue accumulation and ameliorates sarcopenia

Abstract Background Intramuscular adipose tissue (IMAT) formation derived from muscle fibro‐adipogenic progenitors (FAPs) has been recognized as a pathological feature of sarcopenia. This study aimed to explore whether genetic and pharmacological gastric inhibitory polypeptide (GIP) receptor antagon...

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Bibliographic Details
Main Authors: Yuya Takahashi, Hiroki Fujita, Yusuke Seino, Satoko Hattori, Shihomi Hidaka, Tsuyoshi Miyakawa, Atsushi Suzuki, Hironori Waki, Daisuke Yabe, Yutaka Seino, Yuichiro Yamada
Format: Article
Language:English
Published: Wiley 2023-12-01
Series:Journal of Cachexia, Sarcopenia and Muscle
Subjects:
aging
fibro‐adipogenic progenitors
GIP receptor
intramuscular adipose tissue
sarcopenia
Online Access:https://doi.org/10.1002/jcsm.13346

Internet

https://doi.org/10.1002/jcsm.13346

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