Mitochondrial dysfunction and impaired growth of glioblastoma cell lines caused by antimicrobial agents inducing ferroptosis under glucose starvation

Abstract Glioblastoma is a difficult-to-cure disease owing to its malignancy. Under normal circumstances, cancer is dependent on the glycolytic system for growth, and mitochondrial oxidative phosphorylation (OXPHOS) is not well utilized. Here, we investigated the efficacy of mitochondria-targeted gl...

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Bibliographic Details
Main Authors: Kenji Miki, Mikako Yagi, Koji Yoshimoto, Dongchon Kang, Takeshi Uchiumi
Format: Article
Language:English
Published: Nature Publishing Group 2022-10-01
Series:Oncogenesis
Online Access:https://doi.org/10.1038/s41389-022-00437-z