Pharmacokinetics, efficacy and tolerance of cefoxitin in the treatment of cefoxitin-susceptible extended-spectrum beta-lactamase producing Enterobacterales infections in critically ill patients: a retrospective single-center study

Pharmacokinetics, efficacy and tolerance of cefoxitin in the treatment of cefoxitin-susceptible extended-spectrum beta-lactamase producing Enterobacterales infections in critically ill patients: a retrospective single-center study

Abstract Background Cefoxitin is active against some extended-spectrum beta-lactamase-producing Enterobacterales (ESBL-PE), but has not been evaluated so far in the intensive care unit (ICU) settings. Data upon its pharmacokinetics (PK), tolerance and efficacy in critical conditions are scanty. We p...

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Bibliographic Details
Main Authors: Paul Chabert, Judith Provoost, Sabine Cohen, Céline Dupieux-Chabert, Laurent Bitker, Tristan Ferry, Sylvain Goutelle, Jean-Christophe Richard
Format: Article
Language:English
Published: SpringerOpen 2022-09-01
Series:Annals of Intensive Care
Subjects:
Antibacterial chemotherapy
Intensive care
Healthcare-associated pneumonia
Extended-spectrum beta-lactamase
Carbapenem-sparing agents
Cefoxitin
Online Access:https://doi.org/10.1186/s13613-022-01059-9

Internet

https://doi.org/10.1186/s13613-022-01059-9

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