Single-cell analysis of psoriasis resolution demonstrates an inflammatory fibroblast state targeted by IL-23 blockade

Single-cell analysis of psoriasis resolution demonstrates an inflammatory fibroblast state targeted by IL-23 blockade

Abstract Biologic therapies targeting the IL-23/IL-17 axis have transformed the treatment of psoriasis. However, the early mechanisms of action of these drugs remain poorly understood. Here, we perform longitudinal single-cell RNA-sequencing in affected individuals receiving IL-23 inhibitor therapy....

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Bibliographic Details
Main Authors: Luc Francis, Daniel McCluskey, Clarisse Ganier, Treasa Jiang, Xinyi Du-Harpur, Jeyrroy Gabriel, Pawan Dhami, Yogesh Kamra, Sudha Visvanathan, Jonathan N. Barker, Catherine H. Smith, Francesca Capon, Satveer K. Mahil
Format: Article
Language:English
Published: Nature Portfolio 2024-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-44994-w

Internet

https://doi.org/10.1038/s41467-024-44994-w

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