Sphingosine 1 Phosphate (S1P) Receptor 1 Is Decreased in Human Lung Microvascular Endothelial Cells of Smokers and Mediates S1P Effect on Autophagy

Sphingosine 1 Phosphate (S1P) Receptor 1 Is Decreased in Human Lung Microvascular Endothelial Cells of Smokers and Mediates S1P Effect on Autophagy

Destruction of alveoli by apoptosis induced by cigarette smoke (CS) is a major driver of emphysema pathogenesis. However, when compared to cells isolated from non-smokers, primary human lung microvascular endothelial cells (HLMVECs) isolated from chronic smokers are more resilient when exposed to ap...

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Bibliographic Details
Main Authors: Khushboo Goel, Erica L. Beatman, Nicholas Egersdorf, April Scruggs, Danting Cao, Evgeny V. Berdyshev, Kelly S. Schweitzer, Irina Petrache
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Cells
Subjects:
sphingolipids
lung microvascular endothelial cells
chronic obstructive pulmonary disease
autophagy
apoptosis
Online Access:https://www.mdpi.com/2073-4409/10/5/1200

Internet

https://www.mdpi.com/2073-4409/10/5/1200

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