Identification of the flavivirus conserved residues in the envelope protein hinge region for the rational design of a candidate West Nile live-attenuated vaccine

Identification of the flavivirus conserved residues in the envelope protein hinge region for the rational design of a candidate West Nile live-attenuated vaccine

Abstract The flavivirus envelope protein is a class II fusion protein that drives flavivirus-cell membrane fusion. The membrane fusion process is triggered by the conformational change of the E protein from dimer in the virion to trimer, which involves the rearrangement of three domains, EDI, EDII,...

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Bibliographic Details
Main Authors: Bailey E. Maloney, Kassandra L. Carpio, Ashley N. Bilyeu, Danielle R. D. Saunders, So Lee Park, Adrienne E. Pohl, Natalia Costa Ball, Janae L. Raetz, Claire Y. Huang, Stephen Higgs, Alan D. T. Barrett, Gleyder Roman-Sosa, Joanie L. Kenney, Dana L. Vanlandingham, Yan-Jang S. Huang
Format: Article
Language:English
Published: Nature Portfolio 2023-11-01
Series:npj Vaccines
Online Access:https://doi.org/10.1038/s41541-023-00765-0

Internet

https://doi.org/10.1038/s41541-023-00765-0

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