Asymmetric desymmetrization of meso-diols by C2-symmetric chiral 4-pyrrolidinopyridines

Asymmetric desymmetrization of meso-diols by C2-symmetric chiral 4-pyrrolidinopyridines

In this work we developed C2-symmetric chiral nucleophilic catalysts which possess a pyrrolidinopyridine framework as a catalytic site. Some of these organocatalysts effectively promoted asymmetric desymmetrization of meso-diols via enantioselective acylation.

Bibliographic Details
Main Authors: Hartmut Schedel, Keizo Kan, Yoshihiro Ueda, Kenji Mishiro, Keisuke Yoshida, Takumi Furuta, Takeo Kawabata
Format: Article
Language:English
Published: Beilstein-Institut 2012-10-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
acylation
desymmetrization
hydrogen bond
meso-diol
nucleophilic catalyst
organocatalysis
Online Access:https://doi.org/10.3762/bjoc.8.203

Internet

https://doi.org/10.3762/bjoc.8.203

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