Defects in placental syncytiotrophoblast cells are a common cause of developmental heart disease

Defects in placental syncytiotrophoblast cells are a common cause of developmental heart disease

Placental dysfunction can affect heart development, but the prevalence of this causality has not been well established. Here, the authors use mouse genetic tools to show that the placenta may constitute a significant source of congenital heart defects.

Bibliographic Details
Main Authors: Bethany N. Radford, Xiang Zhao, Tali Glazer, Malcolm Eaton, Danielle Blackwell, Shuhiba Mohammad, Lucas Daniel Lo Vercio, Jay Devine, Tali Shalom-Barak, Benedikt Hallgrimsson, James C. Cross, Henry M. Sucov, Yaacov Barak, Wendy Dean, Myriam Hemberger
Format: Article
Language:English
Published: Nature Portfolio 2023-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-36740-5

Internet

https://doi.org/10.1038/s41467-023-36740-5

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