Defects in placental syncytiotrophoblast cells are a common cause of developmental heart disease
Placental dysfunction can affect heart development, but the prevalence of this causality has not been well established. Here, the authors use mouse genetic tools to show that the placenta may constitute a significant source of congenital heart defects.
Main Authors: | Bethany N. Radford, Xiang Zhao, Tali Glazer, Malcolm Eaton, Danielle Blackwell, Shuhiba Mohammad, Lucas Daniel Lo Vercio, Jay Devine, Tali Shalom-Barak, Benedikt Hallgrimsson, James C. Cross, Henry M. Sucov, Yaacov Barak, Wendy Dean, Myriam Hemberger |
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Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2023-03-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-023-36740-5 |
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