Integrated genomic, transcriptomic, and epigenetic analyses identify a leukotriene synthesis-related M2 macrophage gene signature that predicts prognosis and treatment vulnerability in gliomas

Integrated genomic, transcriptomic, and epigenetic analyses identify a leukotriene synthesis-related M2 macrophage gene signature that predicts prognosis and treatment vulnerability in gliomas

The pathological implications of tumor-associated macrophages in the glioma microenvironment have been highlighted, while there lacks a gene signature to characterize the functional status and clinical implications of these cells. Comprehensive bioinformatics approaches were employed to develop an M...

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Bibliographic Details
Main Authors: Hang Ji, Zhihui Liu, Nan Wang, Jiaqi Jin, Jiheng Zhang, Jiawei Dong, Fang Wang, Xiuwei Yan, Qin Gong, Hongtao Zhao, Haogeng Sun, Yongzhe Li, Shaoshan Hu, Chao You
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Immunology
Subjects:
lower-grade glioma
glioblastoma
PI3K/Akt signaling pathway
leukotrienes
M2 macrophage
tumor microenvironment
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.970702/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2022.970702/full

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