Human DUX4 and mouse Dux interact with STAT1 and broadly inhibit interferon-stimulated gene induction

Human DUX4 and mouse Dux interact with STAT1 and broadly inhibit interferon-stimulated gene induction

DUX4 activates the first wave of zygotic gene expression in the early embryo. Mis-expression of DUX4 in skeletal muscle causes facioscapulohumeral dystrophy (FSHD), whereas expression in cancers suppresses IFNγ induction of major histocompatibility complex class I (MHC class I) and contributes to im...

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Bibliographic Details
Main Authors: Amy E Spens, Nicholas A Sutliff, Sean R Bennett, Amy E Campbell, Stephen J Tapscott
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-04-01
Series:eLife
Subjects:
DUX4
DUX
DUXC
STAT1
interferons
interferon stimulated genes
Online Access:https://elifesciences.org/articles/82057

Internet

https://elifesciences.org/articles/82057

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