Human DUX4 and mouse Dux interact with STAT1 and broadly inhibit interferon-stimulated gene induction
DUX4 activates the first wave of zygotic gene expression in the early embryo. Mis-expression of DUX4 in skeletal muscle causes facioscapulohumeral dystrophy (FSHD), whereas expression in cancers suppresses IFNγ induction of major histocompatibility complex class I (MHC class I) and contributes to im...
Main Authors: | Amy E Spens, Nicholas A Sutliff, Sean R Bennett, Amy E Campbell, Stephen J Tapscott |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2023-04-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/82057 |
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