Morc3 silences endogenous retroviruses by enabling Daxx-mediated histone H3.3 incorporation

Morc3 silences endogenous retroviruses by enabling Daxx-mediated histone H3.3 incorporation

Endogenous retroviruses (ERVs) compose a significant portion of mammalian genomes; however, how ERVs are regulated is not well known. Here the authors performed a genome-wide sgRNA screen to identify Morc3 as a mediator of ERV silencing. They show Morc3 associates with the H3.3 chaperone Daxx, and t...

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Bibliographic Details
Main Authors: Sophia Groh, Anna Viktoria Milton, Lisa Katherina Marinelli, Cara V. Sickinger, Angela Russo, Heike Bollig, Gustavo Pereira de Almeida, Andreas Schmidt, Ignasi Forné, Axel Imhof, Gunnar Schotta
Format: Article
Language:English
Published: Nature Portfolio 2021-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-26288-7

Internet

https://doi.org/10.1038/s41467-021-26288-7

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