Morc3 silences endogenous retroviruses by enabling Daxx-mediated histone H3.3 incorporation
Endogenous retroviruses (ERVs) compose a significant portion of mammalian genomes; however, how ERVs are regulated is not well known. Here the authors performed a genome-wide sgRNA screen to identify Morc3 as a mediator of ERV silencing. They show Morc3 associates with the H3.3 chaperone Daxx, and t...
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Bibliographic Details
| Main Authors: |
Sophia Groh,
Anna Viktoria Milton,
Lisa Katherina Marinelli,
Cara V. Sickinger,
Angela Russo,
Heike Bollig,
Gustavo Pereira de Almeida,
Andreas Schmidt,
Ignasi Forné,
Axel Imhof,
Gunnar Schotta |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2021-10-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-021-26288-7
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