Mitotic abnormalities precede microsatellite instability in lynch syndrome-associated colorectal tumourigenesisResearch in context

Mitotic abnormalities precede microsatellite instability in lynch syndrome-associated colorectal tumourigenesisResearch in context

Summary: Background: Lynch syndrome (LS) is one of the most common hereditary cancer syndromes worldwide. Dominantly inherited mutation in one of four DNA mismatch repair genes combined with somatic events leads to mismatch repair deficiency and microsatellite instability (MSI) in tumours. Due to a...

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Main Authors: Marjaana Pussila, Aleksi Laiho, Petri Törönen, Pauliina Björkbacka, Sonja Nykänen, Kirsi Pylvänäinen, Liisa Holm, Jukka-Pekka Mecklin, Laura Renkonen-Sinisalo, Taru Lehtonen, Anna Lepistö, Jere Linden, Satu Mäki-Nevala, Päivi Peltomäki, Minna Nyström
Format: Article
Language:English
Published: Elsevier 2024-05-01
Series:EBioMedicine
Subjects:
Lynch syndrome
Chromosomal instability
Colon cancer
Field defect
Mismatch repair
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396424001464

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http://www.sciencedirect.com/science/article/pii/S2352396424001464

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