RAPP-containing arrest peptides induce translational stalling by short circuiting the ribosomal peptidyltransferase activity

RAPP-containing arrest peptides induce translational stalling by short circuiting the ribosomal peptidyltransferase activity

Abstract Arrest peptides containing RAPP (ArgAlaProPro) motifs have been discovered in both Gram-positive and Gram-negative bacteria, where they are thought to regulate expression of important protein localization machinery components. Here we determine cryo-EM structures of ribosomes stalled on RAP...

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Bibliographic Details
Main Authors: Martino Morici, Sara Gabrielli, Keigo Fujiwara, Helge Paternoga, Bertrand Beckert, Lars V. Bock, Shinobu Chiba, Daniel N. Wilson
Format: Article
Language:English
Published: Nature Portfolio 2024-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-46761-3

Internet

https://doi.org/10.1038/s41467-024-46761-3

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