Dysregulation of the mTOR pathway mediates impairment of synaptic plasticity in a mouse model of Alzheimer's disease.

Dysregulation of the mTOR pathway mediates impairment of synaptic plasticity in a mouse model of Alzheimer's disease.

The mammalian target of rapamycin (mTOR) is an evolutionarily conserved Ser/Thr protein kinase that plays a pivotal role in multiple fundamental biological processes, including synaptic plasticity. We explored the relationship between the mTOR pathway and β-amyloid (Aβ)-induced synaptic dysfunction,...

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Bibliographic Details
Main Authors: Tao Ma, Charles A Hoeffer, Estibaliz Capetillo-Zarate, Fangmin Yu, Helen Wong, Michael T Lin, Davide Tampellini, Eric Klann, Robert D Blitzer, Gunnar K Gouras
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-09-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2942840?pdf=render

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http://europepmc.org/articles/PMC2942840?pdf=render

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