Determination of host proteins composing the microenvironment of coronavirus replicase complexes by proximity-labeling

Determination of host proteins composing the microenvironment of coronavirus replicase complexes by proximity-labeling

Positive-sense RNA viruses hijack intracellular membranes that provide niches for viral RNA synthesis and a platform for interactions with host proteins. However, little is known about host factors at the interface between replicase complexes and the host cytoplasm. We engineered a biotin ligase int...

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Bibliographic Details
Main Authors: Philip V'kovski, Markus Gerber, Jenna Kelly, Stephanie Pfaender, Nadine Ebert, Sophie Braga Lagache, Cedric Simillion, Jasmine Portmann, Hanspeter Stalder, Véronique Gaschen, Rémy Bruggmann, Michael H Stoffel, Manfred Heller, Ronald Dijkman, Volker Thiel
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-01-01
Series:eLife
Subjects:
coronavirus
replicase complex
proximity labeling
virus-host interaction
translation
vesicular transport
Online Access:https://elifesciences.org/articles/42037

Internet

https://elifesciences.org/articles/42037

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