Fin56-induced ferroptosis is supported by autophagy-mediated GPX4 degradation and functions synergistically with mTOR inhibition to kill bladder cancer cells

Fin56-induced ferroptosis is supported by autophagy-mediated GPX4 degradation and functions synergistically with mTOR inhibition to kill bladder cancer cells

Abstract Ferroptosis is a form of regulated cell death that emerges to be relevant for therapy-resistant and dedifferentiating cancers. Although several lines of evidence suggest that ferroptosis is a type of autophagy-dependent cell death, the underlying molecular mechanisms remain unclear. Fin56,...

Full description

Bibliographic Details
Main Authors: Yadong Sun, Niklas Berleth, Wenxian Wu, David Schlütermann, Jana Deitersen, Fabian Stuhldreier, Lena Berning, Annabelle Friedrich, Seda Akgün, María José Mendiburo, Sebastian Wesselborg, Marcus Conrad, Carsten Berndt, Björn Stork
Format: Article
Language:English
Published: Nature Publishing Group 2021-10-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-021-04306-2

Internet

https://doi.org/10.1038/s41419-021-04306-2

Similar Items