Optimal versus Realized Trajectories of Physiological Dysregulation in Aging and their Relation to Sex-Specific Mortality Risk

Optimal versus Realized Trajectories of Physiological Dysregulation in Aging and their Relation to Sex-Specific Mortality Risk

While longitudinal changes in biomarker levels and their impact on health have been characterized for individual markers, little is known about how overall marker profiles may change during aging and affect mortality risk. We implemented the recently developed measure of physiological dysregulation...

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Bibliographic Details
Main Authors: Konstantin G. Arbeev, Alan A Cohen, Liubov S. Arbeeva, Emmanuel eMilot, Eric eStallard, Alexander M Kulminski, Igor eAkushevich, Svetlana eUkraintseva, Kaare eChristensen, Anatoliy I Yashin
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-01-01
Series:Frontiers in Public Health
Subjects:
Mortality
longitudinal data
sex differences
Mahalanobis distance
stochastic process model
Physiological dysregulation
Online Access:http://journal.frontiersin.org/Journal/10.3389/fpubh.2016.00003/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fpubh.2016.00003/full

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