Optimal versus Realized Trajectories of Physiological Dysregulation in Aging and their Relation to Sex-Specific Mortality Risk
While longitudinal changes in biomarker levels and their impact on health have been characterized for individual markers, little is known about how overall marker profiles may change during aging and affect mortality risk. We implemented the recently developed measure of physiological dysregulation...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2016-01-01
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| Series: | Frontiers in Public Health |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fpubh.2016.00003/full |
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| author | Konstantin G. Arbeev Alan A Cohen Liubov S. Arbeeva Emmanuel eMilot Eric eStallard Alexander M Kulminski Igor eAkushevich Svetlana eUkraintseva Kaare eChristensen Kaare eChristensen Anatoliy I Yashin |
| author_facet | Konstantin G. Arbeev Alan A Cohen Liubov S. Arbeeva Emmanuel eMilot Eric eStallard Alexander M Kulminski Igor eAkushevich Svetlana eUkraintseva Kaare eChristensen Kaare eChristensen Anatoliy I Yashin |
| author_sort | Konstantin G. Arbeev |
| collection | DOAJ |
| description | While longitudinal changes in biomarker levels and their impact on health have been characterized for individual markers, little is known about how overall marker profiles may change during aging and affect mortality risk. We implemented the recently developed measure of physiological dysregulation based on the statistical distance of biomarker profiles in the framework of the stochastic process model of aging, using data on blood pressure, heart rate, cholesterol, glucose, hematocrit, body mass index and mortality in the Framingham original cohort. This allowed us to evaluate how physiological dysregulation is related to different aging-related characteristics such as decline in stress resistance and adaptive capacity (which typically are not observed in the data and thus can be analyzed only indirectly), and, ultimately, to estimate how such dynamic relationships increase mortality risk with age. We found that physiological dysregulation increases with age; that increased dysregulation is associated with increased mortality, and increasingly so with age; and that, in most but not all cases, there is a decreasing ability to return quickly to baseline physiological state with age. We also revealed substantial sex differences in these processes, with women becoming dysregulated more quickly but with men showing a much greater sensitivity to dysregulation in terms of mortality risk. |
| first_indexed | 2024-12-14T14:34:13Z |
| format | Article |
| id | doaj.art-7bce6a38d37945a5b15a99da825e4b2a |
| institution | Directory Open Access Journal |
| issn | 2296-2565 |
| language | English |
| last_indexed | 2024-12-14T14:34:13Z |
| publishDate | 2016-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Public Health |
| spelling | doaj.art-7bce6a38d37945a5b15a99da825e4b2a2022-12-21T22:57:43ZengFrontiers Media S.A.Frontiers in Public Health2296-25652016-01-01410.3389/fpubh.2016.00003180877Optimal versus Realized Trajectories of Physiological Dysregulation in Aging and their Relation to Sex-Specific Mortality RiskKonstantin G. Arbeev0Alan A Cohen1Liubov S. Arbeeva2Emmanuel eMilot3Eric eStallard4Alexander M Kulminski5Igor eAkushevich6Svetlana eUkraintseva7Kaare eChristensen8Kaare eChristensen9Anatoliy I Yashin10Duke UniversityUniversity of SherbrookeDuke UniversityUniversity of SherbrookeDuke UniversityDuke UniversityDuke UniversityDuke UniversityUniversity of Southern DenmarkOdense University HospitalDuke UniversityWhile longitudinal changes in biomarker levels and their impact on health have been characterized for individual markers, little is known about how overall marker profiles may change during aging and affect mortality risk. We implemented the recently developed measure of physiological dysregulation based on the statistical distance of biomarker profiles in the framework of the stochastic process model of aging, using data on blood pressure, heart rate, cholesterol, glucose, hematocrit, body mass index and mortality in the Framingham original cohort. This allowed us to evaluate how physiological dysregulation is related to different aging-related characteristics such as decline in stress resistance and adaptive capacity (which typically are not observed in the data and thus can be analyzed only indirectly), and, ultimately, to estimate how such dynamic relationships increase mortality risk with age. We found that physiological dysregulation increases with age; that increased dysregulation is associated with increased mortality, and increasingly so with age; and that, in most but not all cases, there is a decreasing ability to return quickly to baseline physiological state with age. We also revealed substantial sex differences in these processes, with women becoming dysregulated more quickly but with men showing a much greater sensitivity to dysregulation in terms of mortality risk.http://journal.frontiersin.org/Journal/10.3389/fpubh.2016.00003/fullMortalitylongitudinal datasex differencesMahalanobis distancestochastic process modelPhysiological dysregulation |
| spellingShingle | Konstantin G. Arbeev Alan A Cohen Liubov S. Arbeeva Emmanuel eMilot Eric eStallard Alexander M Kulminski Igor eAkushevich Svetlana eUkraintseva Kaare eChristensen Kaare eChristensen Anatoliy I Yashin Optimal versus Realized Trajectories of Physiological Dysregulation in Aging and their Relation to Sex-Specific Mortality Risk Frontiers in Public Health Mortality longitudinal data sex differences Mahalanobis distance stochastic process model Physiological dysregulation |
| title | Optimal versus Realized Trajectories of Physiological Dysregulation in Aging and their Relation to Sex-Specific Mortality Risk |
| title_full | Optimal versus Realized Trajectories of Physiological Dysregulation in Aging and their Relation to Sex-Specific Mortality Risk |
| title_fullStr | Optimal versus Realized Trajectories of Physiological Dysregulation in Aging and their Relation to Sex-Specific Mortality Risk |
| title_full_unstemmed | Optimal versus Realized Trajectories of Physiological Dysregulation in Aging and their Relation to Sex-Specific Mortality Risk |
| title_short | Optimal versus Realized Trajectories of Physiological Dysregulation in Aging and their Relation to Sex-Specific Mortality Risk |
| title_sort | optimal versus realized trajectories of physiological dysregulation in aging and their relation to sex specific mortality risk |
| topic | Mortality longitudinal data sex differences Mahalanobis distance stochastic process model Physiological dysregulation |
| url | http://journal.frontiersin.org/Journal/10.3389/fpubh.2016.00003/full |
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