Propensity for somatic expansion increases over the course of life in Huntington disease
Recent work on Huntington disease (HD) suggests that somatic instability of CAG repeat tracts, which can expand into the hundreds in neurons, explains clinical outcomes better than the length of the inherited allele. Here, we measured somatic expansion in blood samples collected from the same 50 HD...
Main Authors: | , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2021-05-01
|
Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/64674 |