Involvement of Glutathione Depletion in Selective Cytotoxicity of Oridonin to p53-Mutant Esophageal Squamous Carcinoma Cells

Involvement of Glutathione Depletion in Selective Cytotoxicity of Oridonin to p53-Mutant Esophageal Squamous Carcinoma Cells

Oridonin, a diterpenoid compound isolated from traditional Chinese medicine Rabdosia rubescens, has shown antitumor effects to esophageal cancer. However, its molecular mechanism is not fully understood, which limits its clinical application. In the present study, we used RNA-seq analysis to check t...

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Bibliographic Details
Main Authors: Yinchao Li, Nana Li, Jianxiang Shi, Tanzeel Ahmed, Hongmin Liu, Jiancheng Guo, Wenxue Tang, Yongjun Guo, Qi Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Oncology
Subjects:
oridonin
RNA seq
glutathione
esophageal squamous cell carcinoma cells
p53-mutation
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.01525/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2019.01525/full

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