Comparative Transcriptomic Analysis of Temozolomide Resistant Primary GBM Stem-Like Cells and Recurrent GBM Identifies Up-Regulation of the Carbonic Anhydrase <i>CA2</i> Gene as Resistance Factor

Comparative Transcriptomic Analysis of Temozolomide Resistant Primary GBM Stem-Like Cells and Recurrent GBM Identifies Up-Regulation of the Carbonic Anhydrase <i>CA2</i> Gene as Resistance Factor

About 95% of patients with Glioblastoma (GBM) show tumor relapse, leaving them with limited therapeutic options as recurrent tumors are most often resistant to the first line chemotherapy standard Temozolomide (TMZ). To identify molecular pathways involved in TMZ resistance, primary GBM Stem-like Ce...

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Bibliographic Details
Main Authors: Ricarda Hannen, Martin Selmansberger, Maria Hauswald, Axel Pagenstecher, Andrea Nist, Thorsten Stiewe, Till Acker, Barbara Carl, Christopher Nimsky, Jörg Walter Bartsch
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:Cancers
Subjects:
glioblastoma
GBM Stem-like cells
temozolomide
chemoresistance
GBM recurrence
transcriptomics
acetazolamide
carbonic anhydrase 2
Online Access:https://www.mdpi.com/2072-6694/11/7/921

Internet

https://www.mdpi.com/2072-6694/11/7/921

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