Therapeutic role of interferon-γ in experimental autoimmune encephalomyelitis is mediated through a tolerogenic subset of splenic CD11b+ myeloid cells

Therapeutic role of interferon-γ in experimental autoimmune encephalomyelitis is mediated through a tolerogenic subset of splenic CD11b+ myeloid cells

Abstract Cumulative evidence has established that Interferon (IFN)-γ has both pathogenic and protective roles in Multiple Sclerosis and the animal model, Experimental Autoimmune Encephalomyelitis (EAE). However, the underlying mechanisms to the beneficial effects of IFN-γ are not well understood. In...

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Bibliographic Details
Main Authors: Gabriel Arellano, Eric Acuña, Eileah Loda, Lindsay Moore, Juan E. Tichauer, Cristian Castillo, Fabian Vergara, Paula I. Burgos, Pablo Penaloza-MacMaster, Stephen D. Miller, Rodrigo Naves
Format: Article
Language:English
Published: BMC 2024-05-01
Series:Journal of Neuroinflammation
Subjects:
Multiple sclerosis
Experimental autoimmune encephalomyelitis
Interferon-γ
Regulatory T cells
CD11b+ cells
TGF-β
Online Access:https://doi.org/10.1186/s12974-024-03126-3

Internet

https://doi.org/10.1186/s12974-024-03126-3

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