Estimation of Gene Expression at Isoform-level from mRNA-Seq Data by Bayesian Hierarchical Modeling

Estimation of Gene Expression at Isoform-level from mRNA-Seq Data by Bayesian Hierarchical Modeling

mRNA-Seq is a precise and highly reproducible technique for measurement of transcripts levels and yields sequence information of a transcriptome at a single nucleotide base-level thus enabling us to determine splice junctions and alternative splicing events with high confidence. Often analysis of mR...

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Bibliographic Details
Main Authors: Madhuchhanda eBhattacharjee, Ravi eGupta, Ramana eDavuluri
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-11-01
Series:Frontiers in Genetics
Subjects:
Bayesian latent variable modeling
Bayesian t-test
isoform-expression
mRNA-seq
multi-sample comparison
spike-n-slab method
Online Access:http://journal.frontiersin.org/Journal/10.3389/fgene.2012.00239/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fgene.2012.00239/full

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