Polypharmacology-based kinome screen identifies new regulators of KSHV reactivation.

Polypharmacology-based kinome screen identifies new regulators of KSHV reactivation.

Kaposi's sarcoma-associated herpesvirus (KSHV) causes several human diseases including Kaposi's sarcoma (KS), a leading cause of cancer in Africa and in patients with AIDS. KS tumor cells harbor KSHV predominantly in a latent form, while typically <5% contain lytic replicating virus. Be...

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Bibliographic Details
Main Authors: Annabel T Olson, Yuqi Kang, Anushka M Ladha, Songli Zhu, Chuan Bian Lim, Behnam Nabet, Michael Lagunoff, Taranjit S Gujral, Adam P Geballe
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-09-01
Series:PLoS Pathogens
Online Access:https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1011169&type=printable

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https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1011169&type=printable

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