Synthetic Cannabinoids Induce Autophagy and Mitochondrial Apoptotic Pathways in Human Glioblastoma Cells Independently of Deficiency in <i>TP53</i> or <i>PTEN</i> Tumor Suppressors

Synthetic Cannabinoids Induce Autophagy and Mitochondrial Apoptotic Pathways in Human Glioblastoma Cells Independently of Deficiency in <i>TP53</i> or <i>PTEN</i> Tumor Suppressors

Glioblastomas (GBMs) are aggressive brain tumors with frequent genetic alterations in <i>TP53</i> and <i>PTEN </i>tumor suppressor genes rendering resistance to standard chemotherapeutics. Cannabinoid type 1 and 2 (CB1/CB2) receptor expression in GBMs and antitumor activity o...

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Bibliographic Details
Main Authors: Aleksandra Ellert-Miklaszewska, Iwona Anna Ciechomska, Bozena Kaminska
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Cancers
Subjects:
cannabinoids
glioblastoma
apoptosis
autophagy
mitochondrial apoptotic pathway
mTOR
Online Access:https://www.mdpi.com/2072-6694/13/3/419

Internet

https://www.mdpi.com/2072-6694/13/3/419

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