β2 integrins impose a mechanical checkpoint on macrophage phagocytosis

β2 integrins impose a mechanical checkpoint on macrophage phagocytosis

Abstract Phagocytosis is an intensely physical process that depends on the mechanical properties of both the phagocytic cell and its chosen target. Here, we employed differentially deformable hydrogel microparticles to examine the role of cargo rigidity in the regulation of phagocytosis by macrophag...

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Bibliographic Details
Main Authors: Alexander H. Settle, Benjamin Y. Winer, Miguel M. de Jesus, Lauren Seeman, Zhaoquan Wang, Eric Chan, Yevgeniy Romin, Zhuoning Li, Matthew M. Miele, Ronald C. Hendrickson, Daan Vorselen, Justin S. A. Perry, Morgan Huse
Format: Article
Language:English
Published: Nature Portfolio 2024-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-52453-9

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https://doi.org/10.1038/s41467-024-52453-9

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