Mutational landscape of nasopharyngeal carcinoma based on targeted next-generation sequencing: implications for predicting clinical outcomes

Mutational landscape of nasopharyngeal carcinoma based on targeted next-generation sequencing: implications for predicting clinical outcomes

Abstract Background The aim of this study was to draw a comprehensive mutational landscape of nasopharyngeal carcinoma (NPC) tumors and identify the prognostic factors for distant metastasis-free survival (DMFS). Methods A total of forty primary nonkeratinizing NPC patients underwent targeted next-g...

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Bibliographic Details
Main Authors: Zihan Zhou, Peifeng Li, Xianbin Zhang, Juan Xu, Jin Xu, Shui Yu, Dongqing Wang, Wei Dong, Xiujuan Cao, Hongjiang Yan, Mingping Sun, Xiuping Ding, Jun Xing, Peng Zhang, Limin Zhai, Tingyong Fan, Shiyu Tian, Xinhua Yang, Man Hu
Format: Article
Language:English
Published: BMC 2022-05-01
Series:Molecular Medicine
Subjects:
Gene
Tumor mutational burden
Risk score
Nasopharyngeal carcinoma
Distant metastasis-free survival
Target next-generation sequencing
Online Access:https://doi.org/10.1186/s10020-022-00479-4

Internet

https://doi.org/10.1186/s10020-022-00479-4

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