Dopamine neuron morphology and output are differentially controlled by mTORC1 and mTORC2

Dopamine neuron morphology and output are differentially controlled by mTORC1 and mTORC2

The mTOR pathway is an essential regulator of cell growth and metabolism. Midbrain dopamine neurons are particularly sensitive to mTOR signaling status as activation or inhibition of mTOR alters their morphology and physiology. mTOR exists in two distinct multiprotein complexes termed mTORC1 and mTO...

Descripción completa

Detalles Bibliográficos
Autores principales: Polina Kosillo, Kamran M Ahmed, Erin E Aisenberg, Vasiliki Karalis, Bradley M Roberts, Stephanie J Cragg, Helen S Bateup
Formato: Artículo
Lenguaje:English
Publicado: eLife Sciences Publications Ltd 2022-07-01
Colección:eLife
Materias:
mTORC1
mTORC2
raptor
rictor
dopamine neurons
TSC
Acceso en línea:https://elifesciences.org/articles/75398

Internet

https://elifesciences.org/articles/75398

Ejemplares similares