Dopamine neuron morphology and output are differentially controlled by mTORC1 and mTORC2

Dopamine neuron morphology and output are differentially controlled by mTORC1 and mTORC2

The mTOR pathway is an essential regulator of cell growth and metabolism. Midbrain dopamine neurons are particularly sensitive to mTOR signaling status as activation or inhibition of mTOR alters their morphology and physiology. mTOR exists in two distinct multiprotein complexes termed mTORC1 and mTO...

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Bibliographic Details
Main Authors: Polina Kosillo, Kamran M Ahmed, Erin E Aisenberg, Vasiliki Karalis, Bradley M Roberts, Stephanie J Cragg, Helen S Bateup
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-07-01
Series:eLife
Subjects:
mTORC1
mTORC2
raptor
rictor
dopamine neurons
TSC
Online Access:https://elifesciences.org/articles/75398

Internet

https://elifesciences.org/articles/75398

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