Characterization and Molecular Mechanism of Peptide-Conjugated Gold Nanoparticle Inhibiting p53-HDM2 Interaction in Retinoblastoma

Inhibition of the interaction between p53 and HDM2 is an effective therapeutic strategy in cancers that harbor a wild-type p53 protein such as retinoblastoma (RB). Nanoparticle-based delivery of therapeutic molecules has been shown to be advantageous in localized delivery, including to the eye, by o...

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Bibliographic Details
Main Authors:	Sushma Kalmodia, Sowmya Parameswaran, Kalaivani Ganapathy, Wenrong Yang, Colin J. Barrow, Jagat R. Kanwar, Kislay Roy, Madavan Vasudevan, Kirti Kulkarni, Sailaja V. Elchuri, Subramanian Krishnakumar
Format:	Article
Language:	English
Published:	Elsevier 2017-12-01
Series:	Molecular Therapy: Nucleic Acids
Subjects:	human double minute 2 retinoblastoma gold nanoparticles gene expression cell cycle apoptosis in silico p53 peptide molecular mechanism
Online Access:	http://www.sciencedirect.com/science/article/pii/S2162253117302731

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http://www.sciencedirect.com/science/article/pii/S2162253117302731

Characterization and Molecular Mechanism of Peptide-Conjugated Gold Nanoparticle Inhibiting p53-HDM2 Interaction in Retinoblastoma

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