Dopamine induces the accumulation of insoluble prion protein and affects autophagic flux

Dopamine induces the accumulation of insoluble prion protein and affects autophagic flux

Accumulation of protein aggregates is a histopathological hallmark of several neurodegenerative diseases, but in most cases the aggregation occurs without defined mutations or clinical histories, suggesting that certain endogenous metabolites can promote aggregation of specific proteins. One example...

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Bibliographic Details
Main Authors: Marcio Henrique Mello da Luz, Italo Tavares Peres, Tiago Goss dos Santos, Vilma Regina Martins, Marcelo Yudi Icimoto, Kil Sun Lee
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-02-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Autophagy
Dopamine
prion
neurodegeneration
protein aggregation
protein synthesis
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00012/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00012/full

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