Metallothionein-1+2 Deficiency Increases Brain Pathology in Transgenic Mice with Astrocyte-Targeted Expression of Interleukin 6

Metallothionein-1+2 Deficiency Increases Brain Pathology in Transgenic Mice with Astrocyte-Targeted Expression of Interleukin 6

Transgenic expression of IL-6 under the control of the GFAP gene promoter (GFAP-IL6 mice) in the CNS causes significant damage and alters the expression of many genes, including the metallothionein (MT) family, especially in the cerebellum. The crossing of GFAP-IL6 mice with MT-1+2 knock out (MTKO)...

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Bibliographic Details
Main Authors: Mercedes Giralt, Milena Penkowa, Joaquı́n Hernández, Amalia Molinero, Javier Carrasco, Natalia Lago, Jordi Camats, Iain L. Campbell, Juan Hidalgo
Format: Article
Language:English
Published: Elsevier 2002-04-01
Series:Neurobiology of Disease
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996102904808

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http://www.sciencedirect.com/science/article/pii/S0969996102904808

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