Upregulated Ca<sup>2+</sup> Release from the Endoplasmic Reticulum Leads to Impaired Presynaptic Function in Familial Alzheimer’s Disease

Upregulated Ca<sup>2+</sup> Release from the Endoplasmic Reticulum Leads to Impaired Presynaptic Function in Familial Alzheimer’s Disease

Neurotransmitter release from presynaptic terminals is primarily regulated by rapid Ca<sup>2+</sup> influx through membrane-resident voltage-gated Ca<sup>2+</sup> channels (VGCCs). Moreover, accumulating evidence indicates that the endoplasmic reticulum (ER) is extensively pr...

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Bibliographic Details
Main Authors: Temitope Adeoye, Syed I. Shah, Angelo Demuro, David A. Rabson, Ghanim Ullah
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Cells
Subjects:
neuronal calcium signaling
endoplasmic reticulum
Alzheimer’s
IP<sub>3</sub>R
neurotransmitter release
synaptic transmission
Online Access:https://www.mdpi.com/2073-4409/11/14/2167

Internet

https://www.mdpi.com/2073-4409/11/14/2167

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