Upregulated Ca<sup>2+</sup> Release from the Endoplasmic Reticulum Leads to Impaired Presynaptic Function in Familial Alzheimer’s Disease
Neurotransmitter release from presynaptic terminals is primarily regulated by rapid Ca<sup>2+</sup> influx through membrane-resident voltage-gated Ca<sup>2+</sup> channels (VGCCs). Moreover, accumulating evidence indicates that the endoplasmic reticulum (ER) is extensively pr...
Main Authors: | Temitope Adeoye, Syed I. Shah, Angelo Demuro, David A. Rabson, Ghanim Ullah |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2022-07-01
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Series: | Cells |
Subjects: | |
Online Access: | https://www.mdpi.com/2073-4409/11/14/2167 |
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